About antiSMASH

antiSMASH allows the rapid genome-wide identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genomes. It integrates and cross-links with a large number of in silico secondary metabolite analysis tools that have been published earlier.

antiSMASH is powered by several open source tools: NCBI BLAST+, HMMer 3, Muscle 3, Glimmer 3, FastTree, TreeGraph 2, Indigo-depict, PySVG and JQuery SVG.

antiSMASH contributors

antiSMASH is an international collaboration project, which was initially started by the labs of Wolfgang Wohlleben (University Tübignen) and Eriko Takano and Rainer Breitling (University Groningen/Manchester). Currently, the project is coordinated by Marnix Medema (University of Wageningen) and Tilmann Weber/Kai Blin (Technical University of Denmark) with numerous collaborators all over the world.

List of contributors

How to cite

If you have found antiSMASH useful, please cite:

  • Blin, K., Wolf, T., Chevrette, M.G., Lu, X., Schwalen, C.J., Kautasar, S.A., Suarez Duran, H.G., de los Santos, E.L.C., Kim, H.U., Nave, M., et al. (2017). antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification. Nucleic Acids Res 45, W36-W41.
  • Weber, T., Blin, K., Duddela, S., Krug, D., Kim, H.U., Bruccoleri, R., Lee, S.Y., Fischbach, M.A., Müller, R., Wohlleben, W., et al. (2015). antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res 43, W237-W243.
  • Blin, K., Medema, M.H., Kazempour, D., Fischbach, M., Breitling, R., Takano, E., and Weber, T. (2013). antiSMASH 2.0 – a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res 41, W204-W212. M* edema, M.H., Blin, K., Cimermancic, P., de Jager, V., Zakrzewski, P., Fischbach, M.A., Weber, T., Takano, E., and Breitling, R. (2011). antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res 39, W339-W346.

Further reading

  • Villebro, R., Shaw, S., Blin, K., and Weber, T. (2019). Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH. J Ind Microbiol Biotechnol, doi: 10.1007/s10295-10018-02131-10299.
  • Blin, K., Kim, H.U., Medema, M.H., and Weber, T. (2017). Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters. Brief Bioinform, doi: 10.1093/bib/bbx1146.
  • Blin, K., Kazempour, D., Wohlleben, W., and Weber, T. (2014). Improved lanthipeptide detection and prediction for antiSMASH. PLoS ONE 9, e89420.