Cluster Types#

antiSMASH uses some abbreviations internally to refer to the different types of secondary metabolite clusters, a short explanation of the different types can be found below:

Current Types#

Label Description Added Last updated
acyl_amino_acids N-acyl amino acid cluster 4.0 4.1
aminocoumarin Aminocoumarin cluster <= 3.0 <= 3.0
amglyccycl Aminoglycoside/aminocyclitol cluster <= 3.0 <= 3.0
arylpolyene Aryl polyene cluster <= 3.0 <= 3.0
betalactone beta-lactone containing protease inhibitor 5.0 5.0
blactam β-lactam cluster <= 3.0 <= 3.0
bottromycin Bottromycin cluster <= 3.0 <= 3.0
butyrolactone Butyrolactone cluster <= 3.0 <= 3.0
CDPS tRNA-dependent cyclodipeptide synthases 5.0 5.0
cyanobactin Cyanobactins like patellamide (AY986476) <= 3.0 6.0
ectoine Ectoine cluster <= 3.0 <= 3.0
fatty_acid Fatty acid cluster (loose strictness, likely from primary metabolism) <= 3.0 4.2
furan Furan cluster <= 3.0 5.0
fungal-RiPP Fungal RiPP with POP or UstH peptidase types and a modification 5.0 5.0
glycocin Glycocin cluster <= 3.0 <= 3.0
guanidinotides Pheganomycin-style protein ligase-containing cluster 4.0 6.0
halogenated Cluster containing a halogenase and thus potentially generating a halogenated product 5.0 5.0
hglE-KS heterocyst glycolipid synthase-like PKS 5.0 5.0
hserlactone Homoserine lactone cluster <= 3.0 <= 3.0
indole Indole cluster <= 3.0 4.0
LAP Linear azol(in)e-containing peptides <= 3.0 6.0
ladderane Ladderane cluster <= 3.0 <= 3.0
lantipeptide class I Class I lanthipeptide clusters like nisin 4.2 6.0
lantipeptide class II Class II lanthipeptide clusters like mutacin II (U40620) 4.2 6.0
lantipeptide class III Class III lanthipeptide clusters like labyrinthopeptin (FN178622) 4.2 6.0
lantipeptide class IV Class IV lanthipeptide clusters like venezuelin (HQ328852) 4.2 6.0
lantipeptide class V Glycosylated lanthipeptide/linaridin hybrids like MT210103 5.1 6.0
lassopeptide Lasso peptide cluster <= 3.0 5.0
linaridin Linaridin cluster <= 3.0 <= 3.0
lipolanthine Lanthipeptide class containing N-terminal fatty acids such as MG673929 5.0 5.0
melanin Melanin cluster <= 3.0 <= 3.0
microviridin Microviridin cluster <= 3.0 <= 3.0
NAGGN N-acetylglutaminylglutamine amide 5.0 5.0
NAPAA non-alpha poly-amino acids like e-Polylysin 6.0 6.0
nrps Non-ribosomal peptide synthetase cluster <= 3.0 <= 3.0
nrps-like NRPS-like fragment 5.0 5.0
nucleoside Nucleoside cluster <= 3.0 5.0
oligosaccharide Oligosaccharide cluster <= 3.0 <= 3.0
other Cluster containing a secondary metabolite-related protein that does not fit into any other category 4.0 5.0
PBDE Polybrominated diphenyl ether cluster 4.1 4.1
phenazine Phenazine cluster <= 3.0 <= 3.0
phosphoglycolipid Phosphoglycolipid cluster <= 3.0 <= 3.0
phosphonate Phosphonate cluster <= 3.0 <= 3.0
PKS-like Other types of PKS cluster 5.0 5.0
PpyS-KS PPY-like pyrone cluster 4.2 4.2
proteusin Proteusin cluster <= 3.0 <= 3.0
PUFA Polyunsaturated fatty acid cluster <= 3.0 <= 3.0
pyrrolidine Pyrrolidines like described in BGC0001510 6.0 6.0
ranthipeptide Cys-rich peptides (aka. SCIFF: six Cys in fourty-five) like in CP001581:3481278-3502939 6.0 6.0
RaS-RiPP Streptide-like thioether-bond RiPPs 5.0 5.0
redox-cofactor Redox-cofactors such as PQQ (NC_021985:1458906-1494876) 6.0 6.0
resorcinol Resorcinol cluster <= 3.0 <= 3.0
RiPP-like Other unspecified ribosomally synthesised and post-translationally modified peptide product (RiPP) cluster 4.1 6.0
RRE-containing RRE-element containing cluster 6.0 6.0
saccharide Saccharide cluster (loose strictness, likely from primary metabolism) <= 3.0 <= 3.0
sactipeptide Sactipeptide cluster <= 3.0 6.0
siderophore Siderophore cluster <= 3.0 <= 3.0
T1PKS Type I PKS (Polyketide synthase) <= 3.0 <= 3.0
T2PKS Type II PKS <= 3.0 5.0
T3PKS Type III PKS <= 3.0 <= 3.0
terpene Terpene <= 3.0 4.1
thioamitides Thioamitide RiPPs as found in JOBF01000011 5.1 6.0
thioamide-NRP Thioamide-containing non-ribosomal peptide 5.0 5.0
thiopeptide Thiopeptide cluster 4.2 5.0
transAT-PKS Trans-AT PKS <= 3.0 5.0
transAT-PKS-like Trans-AT PKS fragment, with trans-AT domain not found <= 5.0 5.0
tropodithietic-acid Tropodithietic acid cluster 5.0 5.0

Obsolete/Previous Types#

Label Description Added Removed Notes
bacteriocin Bacteriocin or other unspecified ribosomally synthesised and post-translationally modified peptide product (RiPP) cluster 4.1 6.0 Renamed to RiPP-like
fused Pheganomycin-style protein ligase-containing cluster 4.0 6.0 Renamed to guanidinotides
head_to_tail Head-to-tail cyclised (subtilosin-like) cluster <= 3.0 6.0 Merged into sactipeptides
lanthidin Glycosylated lanthipeptide/linaridin hybrids like MT210103 5.1 6.0 Renamed to lanthipeptide class V
lanthipeptide Lanthipeptides 4.2 6.0 Split into subclasses, e.g. lanthipeptide class I
TfuA-related TfuA-related RiPPs 5.1 6.0 Renamed to thioamitides
otherks Other types of PKS cluster <= 3.0 5.0 Split into PKS-like and hglE-KS
microcin Microcin cluster <= 3.0 5.0 Merged into lasso peptide
cf_saccharide Possible saccharide cluster <= 3.0 5.0 Renamed to saccharide
cf_fatty_acid Possible fatty acid cluster <= 3.0 5.0 Renamed to fatty_acid
cf_putative Putative cluster of unknown type identified with the ClusterFinder algorithm <= 3.0 5.0 These predictions are now subregions, not clusters