Cluster Types

antiSMASH uses some abbreviations internally to refer to the different types of secondary metabolite clusters, a short explanation of the different types can be found below:

Current Types

Label Description Added Last updated
T1PKS Type I PKS (Polyketide synthase) <= 3.0 <= 3.0
T2PKS Type II PKS <= 3.0 5.0
T3PKS Type III PKS <= 3.0 <= 3.0
transAT-PKS Trans-AT PKS <= 3.0 5.0
transAT-PKS Trans-AT PKS fragment, with trans-AT domain not found <= 5.0 5.0
PpyS-KS PPY-like pyrone cluster 4.2 4.2
hglE-KS heterocyst glycolipid synthase-like PKS 5.0 5.0
CDPS tRNA-dependent cyclodipeptide synthases 5.0 5.0
PKS-like Other types of PKS cluster 5.0 5.0
arylpolyene Aryl polyene cluster <= 3.0 <= 3.0
resorcinol Resorcinol cluster <= 3.0 <= 3.0
ladderane Ladderane cluster <= 3.0 <= 3.0
PUFA Polyunsaturated fatty acid cluster <= 3.0 <= 3.0
nrps Non-ribosomal peptide synthetase cluster <= 3.0 <= 3.0
nrps-like NRPS-like fragment 5.0 5.0
thioamide-NRP thioamide-containing non-ribosomal peptide 5.0 5.0
terpene Terpene <= 3.0 4.1
lanthipeptide Lanthipeptide cluster 4.2 5.0
lipolanthine Lanthipeptide class containing N-terminal fatty acids 5.0 5.0
bacteriocin Bacteriocin or other unspecified ribosomally synthesised and post-translationally modified peptide product (RiPP) cluster 4.1 5.0
betalactone beta-lactone containing protease inhibitor 5.0 5.0
thiopeptide Thiopeptide cluster 4.2 5.0
linaridin Linaridin cluster <= 3.0 <= 3.0
cyanobactin Cyanobactin cluster <= 3.0 <= 3.0
glycocin Glycocin cluster <= 3.0 <= 3.0
LAP Linear azol(in)e-containing peptides <= 3.0 5.0
lassopeptide Lasso peptide cluster <= 3.0 5.0
sactipeptide Sactipeptide cluster <= 3.0 4.0
bottromycin Bottromycin cluster <= 3.0 <= 3.0
head_to_tail Head-to-tail cyclised (subtilosin-like) cluster <= 3.0 <= 3.0
microviridin Microviridin cluster <= 3.0 <= 3.0
proteusin Proteusin cluster <= 3.0 <= 3.0
blactam β-lactam cluster <= 3.0 <= 3.0
amglyccycl Aminoglycoside/aminocyclitol cluster <= 3.0 <= 3.0
aminocoumarin Aminocoumarin cluster <= 3.0 <= 3.0
siderophore Siderophore cluster <= 3.0 <= 3.0
ectoine Ectoine cluster <= 3.0 <= 3.0
butyrolactone Butyrolactone cluster <= 3.0 <= 3.0
indole Indole cluster <= 3.0 4.0
nucleoside Nucleoside cluster <= 3.0 5.0
phosphoglycolipid Phosphoglycolipid cluster <= 3.0 <= 3.0
melanin Melanin cluster <= 3.0 <= 3.0
oligosaccharide Oligosaccharide cluster <= 3.0 <= 3.0
furan Furan cluster <= 3.0 5.0
hserlactone Homoserine lactone cluster <= 3.0 <= 3.0
phenazine Phenazine cluster <= 3.0 <= 3.0
phosphonate Phosphonate cluster <= 3.0 <= 3.0
fused Pheganomycin-style protein ligase-containing cluster 4.0 4.0
PBDE Polybrominated diphenyl ether cluster 4.1 4.1
acyl_amino_acids N-acyl amino acid cluster 4.0 4.1
NAGGN N-acetylglutaminylglutamine amide 5.0 5.0
RaS-RiPP Streptide-like thioether-bond RiPPs 5.0 5.0
fungal-RiPP Fungal RiPP with POP or UstH peptidase types and a modification 5.0 5.0
other Cluster containing a secondary metabolite-related protein that does not fit into any other category 4.0 5.0
cf_saccharide Possible saccharide cluster <= 3.0 <= 3.0
cf_fatty_acid Possible fatty acid cluster <= 3.0 4.2

Obsolete/Previous Types

Label Description Added Removed Notes
otherks Other types of PKS cluster <= 3.0 5.0 Split into PKS-like and hglE-KS
microcin Microcin cluster <= 3.0 5.0 Merged into lasso peptide
cf_putative Putative cluster of unknown type identified with the ClusterFinder algorithm <= 3.0 5.0 These predictions are now subregions, not clusters