Protocluster Types#

antiSMASH uses some abbreviations internally to refer to the different types of secondary metabolite clusters, a short explanation of the different types can be found below:

Current Types#

Label Description Added Last updated
2dos 2-deoxy-streptamine aminoglycoside 7.0 7.0
acyl_amino_acids N-acyl amino acid 4.0 4.1
aminocoumarin Aminocoumarin <= 3.0 <= 3.0
aminopolycarboxylic-acid Aminopolycarboxylic acid metallophores (doi:10.1039/C8MT00009C) 7.0 7.0
amglyccycl Aminoglycoside/aminocyclitol <= 3.0 <= 3.0
arylpolyene Aryl polyene <= 3.0 <= 3.0
betalactone Beta-lactone containing protease inhibitor 5.0 5.0
blactam β-lactam <= 3.0 <= 3.0
bottromycin Bottromycin <= 3.0 <= 3.0
butyrolactone Butyrolactone <= 3.0 <= 3.0
CDPS tRNA-dependent cyclodipeptide synthases 5.0 5.0
crocagin Crocagin-like 7.0 7.0
cyanobactin Cyanobactins like patellamide (AY986476) <= 3.0 7.0
cyclic-lactone-autoinducer agrD-like cyclic lactone autoinducer peptides (AF001782) 6.0 6.0
ectoine Ectoine <= 3.0 <= 3.0
epipeptide D-amino-acid containing RiPPs such as yydF (D78193) 6.0 6.0
fatty_acid Fatty acid (loose strictness, likely from primary metabolism) <= 3.0 4.2
furan Furan <= 3.0 5.0
fungal-RiPP Fungal RiPP with POP or UstH peptidase types and a modification 5.0 5.0
fungal-RiPP-like Fungal RiPP-likes 7.0 7.0
glycocin Glycocin <= 3.0 <= 3.0
guanidinotides Pheganomycin-style protein ligase-containing cluster 4.0 6.0
halogenated Halogenase-containing cluster, potentially generating a halogenated product 5.0 5.0
hglE-KS Heterocyst glycolipid synthase-like PKS 5.0 5.0
hserlactone Homoserine lactone <= 3.0 <= 3.0
indole Indole <= 3.0 4.0
LAP Linear azol(in)e-containing peptides <= 3.0 6.0
ladderane Ladderane <= 3.0 <= 3.0
lanthipeptide class I Class I lanthipeptides like nisin 4.2 6.0
lanthipeptide class II Class II lanthipeptides like mutacin II (U40620) 4.2 6.0
lanthipeptide class III Class III lanthipeptides like labyrinthopeptin (FN178622) 4.2 6.0
lanthipeptide class IV Class IV lanthipeptides like venezuelin (HQ328852) 4.2 6.0
lanthipeptide class V Glycosylated lanthipeptide/linaridin hybrids like MT210103 5.1 6.0
lassopeptide Lasso peptide <= 3.0 5.0
linaridin Linear arid peptide such as cypemycin (HQ148718) and salinipeptin (MG788286) <= 3.0 <= 3.0
lipolanthine Lanthipeptide class containing N-terminal fatty acids such as MG673929 5.0 5.0
melanin Melanin <= 3.0 <= 3.0
methanobactin Copper-chelating/transporting peptides (doi:10.1126/science.aap9437) 7.0 7.0
microviridin Microviridin <= 3.0 <= 3.0
mycosporine-like Molecules containing mycosporine-like amino acid 7.0 7.0
NAGGN N-acetylglutaminylglutamine amide 5.0 5.0
NAPAA Non-alpha poly-amino acids like e-Polylysin 6.0 7.0
NRPS Non-ribosomal peptide synthetase <= 3.0 6.0
NRPS-like NRPS-like fragment 5.0 5.0
NRP-metallophore Non-ribosomal peptide metallophores 7.0 7.0
NRPS-independent-siderophore IucA/IucC-like siderophores (siderophore prior to 7.0) 7.0 7.0
nucleoside Nucleoside <= 3.0 5.0
oligosaccharide Oligosaccharide <= 3.0 <= 3.0
opine-like-metallophore Opine-like zincophores like staphylopine (doi:10.1128/mSystems.00554-20) 7.0 7.0
other Cluster containing a secondary metabolite-related protein that does not fit into any other category 4.0 5.0
PBDE Polybrominated diphenyl ether 4.1 4.1
phenazine Phenazine <= 3.0 <= 3.0
phosphoglycolipid Phosphoglycolipid <= 3.0 <= 3.0
phosphonate Phosphonate <= 3.0 7.0
phosphonate-like Phosphonate-like (prior to 7.0 this was the phosphonate rule) 7.0 7.0
PKS-like Other types of PKS 5.0 5.0
PpyS-KS PPY-like pyrone 4.2 4.2
prodigiosin Serratia-type non-traditional PKS prodigiosin biosynthesis pathway 6.0 6.0
proteusin Proteusin <= 3.0 <= 3.0
PUFA Polyunsaturated fatty acid <= 3.0 <= 3.0
pyrrolidine Pyrrolidines like described in BGC0001510 6.0 6.0
ranthipeptide Cys-rich peptides (aka. SCIFF: six Cys in fourty-five) like in CP001581:3481278-3502939 6.0 6.0
RaS-RiPP Streptide-like thioether-bond RiPPs 5.0 5.0
redox-cofactor Redox-cofactors such as PQQ (NC_021985:1458906-1494876) 6.0 6.0
resorcinol Resorcinol <= 3.0 <= 3.0
RiPP-like Other unspecified ribosomally synthesised and post-translationally modified peptide product (RiPP) 4.1 7.0
RRE-containing RRE-element containing cluster 6.0 6.0
saccharide Saccharide (loose strictness, likely from primary metabolism) <= 3.0 <= 3.0
sactipeptide Sactipeptide <= 3.0 6.0
spliceotide RiPPs containing plpX type spliceases (NZ_KB235920:17899-42115) 6.0 6.0
T1PKS Type I PKS (Polyketide synthase) <= 3.0 <= 3.0
T2PKS Type II PKS <= 3.0 5.0
T3PKS Type III PKS <= 3.0 <= 3.0
terpene Terpene <= 3.0 4.1
thioamitides Thioamitide RiPPs as found in JOBF01000011 5.1 6.0
thioamide-NRP Thioamide-containing non-ribosomal peptide 5.0 5.0
thiopeptide Thiopeptide 4.2 5.0
transAT-PKS Trans-AT PKS <= 3.0 5.0
transAT-PKS-like Trans-AT PKS fragment, with trans-AT domain not found <= 5.0 5.0
tropodithietic-acid Tropodithietic acid 5.0 5.0

Obsolete/Previous Types#

Label Description Added Removed Notes
siderophore Siderophore <= 3.0 7.0 Renamed to NRPS-independent-siderophore
bacteriocin Bacteriocin or other unspecified ribosomally synthesised and post-translationally modified peptide product (RiPP) 4.1 6.0 Renamed to RiPP-like
fused Pheganomycin-style protein ligase-containing cluster 4.0 6.0 Renamed to guanidinotides
head_to_tail Head-to-tail cyclised RiPP (subtilosin-like) <= 3.0 6.0 Merged into sactipeptides
lanthidin Glycosylated lanthipeptide/linaridin hybrids like MT210103 5.1 6.0 Renamed to lanthipeptide class V
lanthipeptide Lanthipeptides 4.2 6.0 Split into subclasses, e.g. lanthipeptide class I
TfuA-related TfuA-related RiPPs 5.1 6.0 Renamed to thioamitides
otherks Other types of PKS <= 3.0 5.0 Split into PKS-like and hglE-KS
microcin Microcin <= 3.0 5.0 Merged into lasso peptide
cf_saccharide Possible saccharide <= 3.0 5.0 Renamed to saccharide
cf_fatty_acid Possible fatty acid <= 3.0 5.0 Renamed to fatty_acid
cf_putative Putative cluster of unknown type identified with the ClusterFinder algorithm <= 3.0 5.0 These predictions are now subregions, not clusters